Brian Holloway is a former professional offensive tackle. After a standout high school football career, Holloway was recruited by Bill Walsh to Stanford University, where he earned All-American honors.

Holloway played for the New England Patriots and Los Angeles Raiders from 1981 to 1988. Brian Holloway was selected by the New England Patriots in the first round (19th overall) of the 1981 NFL Draft out of Stanford. In the strike-shortened 1982 NFL season, Holloway started 9 of 9 games as he became the starting left offensive tackle, next to guard John Hannah, and missed only one start up to the end of the 1986 NFL season. After beating the New York Jets in a wild-card game of the 1985-86 NFL playoffs, the Patriots beat the Los Angeles Raiders on the road in the divisional round with a strong running game. The line then destroyed the Miami Dolphins' run defense on the road by accumulating 255 yards, 105 of them by James, winning the AFC title. However, they could not run over the legendary Chicago Bears defense of 1985 in Super Bowl XX.

Holloway was one of the most dominating offensive tackles in his era, as indicated in part by three Pro Bowl selections from 1983 to 1985. Holloway's father also played professionally with the New England Patriots, many years before him.